Rapamycin — the first drug aimed at the disease itself

One sentence has repeated through this whole bible: "no drug has been proven to slow asymptomatic HCM." As the medications article showed, atenolol, ACE inhibitors and diltiazem all failed that test, and every drug we had was a complication-blocker — against clots and water, never the disease. That sentence is finally being shaken. Rapamycin (sirolimus) became, in a 2023 clini…